Innovative solutions to improve citizens' health and well-being: Horizon Europe Cluster 1 calls are now open.

The 2026 calls for proposals have been published within the framework of Horizon Europe Cluster 1 – 'Health' The aim is to support innovative solutions capable of improving the health and well-being of citizens of all ages by generating new knowledge, developing innovative solutions, and integrating, where relevant, a gender perspective to prevent, diagnose, monitor, treat, and cure diseases. Specifically, the open calls are:

For the destination 'Staying Healthy in a Rapidly Changing Society expiring on April 16th:

HORIZON-HLTH-2026-01-STAYHLTH-02: Behavioral Interventions as Primary Prevention of Noncommunicable Diseases (NCDs) among Young People. RIA, max. €10 million per project, 2 solutions funded.
HORIZON-HLTH-2026-01-STAYHLTH-03: Building public trust and awareness in the life sciences. CSA, max. €1.9 million, 1 solution to be funded.

For the destination 'Living and working in a health-promoting environment expiring on April 16th:

HORIZON-HLTH-2026-01-ENVHLTH-01: Towards a better understanding and anticipation of the health impacts of climate change. RIA, max. €8 million per project, 7 projects to be funded.
HORIZON-HLTH-2026-01-ENVHLTH-04: Towards climate-resilient, prepared, and zero-carbon populations and health systems. RIA, max. €8 million per project, 6 projects to be funded.
HORIZON-HLTH-2026-01-ENVHLTH-05: Support for a multilateral initiative on climate change and health research. CSA, up to €3 million to fund one project.

For the destination 'Addressing disease and reducing the burden of disease' expiring on April 16th:

HORIZON-HLTH-2026-01-DISEASE-02: Innovative interventions to prevent the harmful effects of digital technology use on the mental health of children and young adults. RIA, max. €8 million per project, 6 solutions to be funded.
HORIZON-HLTH-2026-01-DISEASE-03: Promote research on the prevention, diagnosis, and management of long-term post-infection conditions. RIA, max. €8 million per project, 5 solutions to be funded.
HORIZON-HLTH-2026-01-DISEASE-04: Development of novel vaccines for viral pathogens with epidemic potential. RIA, max. €11 million per project, 5 solutions to be funded.
HORIZON-HLTH-2026-01-DISEASE-09: Multisectoral approach to address chronic noncommunicable diseases: Implementation research maximizing collaboration and coordination with sectors and in non-health system settings (GACD). RIA, max. €4 million per project, 3 solutions to be funded.
HORIZON-HLTH-2026-01-DISEASE-11: Understanding gender- and/or sex-specific mechanisms of cardiovascular disease: determinants, risk factors, and pathways. RIA, €7 million per project, 6 solutions to be funded.
HORIZON-HLTH-2026-01-DISEASE-15: Accelerating Innovation in Cardiovascular Health. CSA, max. €1.9 for a single project.

For the destination 'Ensuring equal access to innovative, sustainable and high-quality healthcare expiring on April 16th:

HORIZON-HLTH-2026-01-CARE-01: Public procurement of innovative solutions to improve citizens' access to healthcare through integrated or customized approaches. Public Procurement of Innovation Solutions, max. €8 million per project, 4 solutions to be funded.
HORIZON-HLTH-2026-01-CARE-03: Identifying and addressing low-value care in health and care systems. RIA, max. €10 million per project, 4 solutions funded.

For the destination Developing and using new tools, technologies, and digital solutions for a healthy society expiring on April 16th:

HORIZON-HLTH-2026-01-TOOL-03: Integrating New Approach Methodologies (NAMs) to Advance Biomedical Research and Regulatory Testing. RIA, up to €8 million to fund 7 projects.
HORIZON-HLTH-2026-01-TOOL-05: Pilot actions for follow-on funding: leveraging EU-funded collaborative research in regenerative medicine. AI, max. €8 million per project, 4 solutions to be funded.
HORIZON-HLTH-2026-01-TOOL-06: Support for the European Research Area (ERA) action to accelerate new approach methodologies (NAMs) to advance biomedical research and the testing of medicinal products and medical devices. CSA, €2.9 million to fund a single project.
HORIZON-HLTH-2026-01-TOOL-07: Creation of a European network of centers of excellence (CoE) for advanced therapy medicinal products (ATMPs). CSA, €3.9 million to fund a single project.

For the destination Maintaining an innovative, sustainable, and competitive EU healthcare sector expiring on April 16th:

HORIZON-HLTH-2026-01-IND-03: Regulatory Science to Support the Translational Development of Patient-Centered Health Technologies. RIA, max. €6 million per project, 4 projects to be funded.

For more information: info@iniziativa.cc

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Success Cases

MISENO

Multipurpose Ital-GovSatCom application Services for Emerging user Needs and Objectives

Contract: Innovation Agreements for the Space Economy
Project cost: €8.987.370,13
Non-repayable contribution: €4.192.681,20
Date: June 2020

Integrated Services Consortium

Facility services management project for the ORN Moscati company in Avellino

Date: 2024

Engineering SpA

Consultancy and support for economic-financial and procedural aspects in all phases of the procedure relating to a PPP initiative (pursuant to paragraph 15 art. 183 Legislative Decree 50/2016) relating to an intervention of "Implementation of the Physical and IT infrastructures for the management of the drug cycle, treatment aids and physical and information flows for the Ragusa ASP"

Sector: Hospital
Date: 2019

CA.MPANIA

MEASUREMENT CHARACTERIZATION OF POLYMERS: NON-INVASIVE ANALYSIS

Contract: Campania startUp 2020
Project cost: €78.862,00
Contribution: €67.032,70
Date: June 2023

ISTHMUS

Smart Infrastructures for Transport and Mobility

Contract: Major R&D Projects
Project cost: €5.578.468,75
Contribution to spending: €1.834.279,63
Concessionary Financing: €1.115.693,75
Date: June 2021

Provincial Palace ProjektBau

“Project Financing for the construction and management of a property to be used as public offices and related appurtenances for the Autonomous Province of Bolzano” – Proposal pursuant to paragraph 15 art. 183 Legislative Decree 50/2016 for a Project Financing initiative - Technical assistance to the proponent, Projektbau Srl, with particular reference to the activities of: i. PEF preparation and sworn certification support, ii. Support in drafting the feasibility study; iii. Public Sector Comparator and Value for Money editorial team; iv. Drafting Cost-Benefit Analysis; v. Supporting the legal team for the development of the draft agreement; you. Support in drafting the document "Specification of the characteristics of the service and management"

Sector: Sports facilities
Date: 2016

San Michele SRL Nursing Home

The company has acquired additional diagnostic equipment to expand the services offered.

Contract: ZES Credit - Article 16 of Legislative Decree 19.09.2023 n. 124
Project cost: €850.920,00
Contribution: €340.367,00

Solacem F2i

Sale of the majority stake to F2i; Iniziativa acted as financial advisor to the sellers.

Sector: Infrastructure
Deal: Undisclosed
Date: 2026

MUNICIPALITY OF LUCCA – PORTA ELISA STADIUM

Technical assistance to the Grantor in the evaluation of a Project Financing proposal relating to a "Recovery with demolition and reconstruction of the "Porta Elisa Municipal Stadium" of Lucca and restoration of the historic grandstand" presented pursuant to Law 147/2013 and subsequently adjusted in compliance to Legislative Decree 38/2021

Sector: Sports Facilities PPP
Date: 2021

Ferentillo Sports Association

Redevelopment of the Ferentillo (TR) Municipal Sports Center

Date: 2018-2021/XNUMX/XNUMX

Technical assistance

Technical, specialist and management assistance service for projects financed under the Pact for the City of Naples FSC 2014-2020

Sector: Local authorities - Technical assistance for FSC programming, monitoring and reporting
Date: 2018 - 2023
FSC resource allocation assigned to the Metropolitan City of Naples: €310.999.041

“NSS2023

Next Smart system in a marine environment

Contract: Innovation Agreement
Project cost: €6.431.394,25
Contribution to spending: €2.000.354,01
Date: September 2020

SGAM SpA

Expansion of production capacity through technological adaptation and extraordinary maintenance interventions of the production plant located in the Municipality of Pratella (CE).

Contract: Development Contract
Project cost: €28.116.140,00
Non-refundable contribution: €7.431.980,00
Date: September 2016

General Company of Mineral Waters SpA (formerly Acqua Lete SpA)

Between 2019 and 2023, the company invested in the construction of a production line for bottling 1.5-liter mineral water.

Contract: Credito Mezzogiorno - Article 1, paragraphs 98 to 108, of Law No. 208 of 28 December 2015, and subsequent amendments
Project cost: €6.101.000,00
Contribution: €1.525.000,00

Sustainability Report

Support in the preparation of the corporate sustainability report and definition of the ESG strategy and indicators for monitoring sustainable variables

Sector: Railway, telecommunications and automation
Turnover: €27.506.749
Date: 2023

SEGLUCO

“Eating well and gluten-free: development of a gluten-free croissant (already cooked and frozen) with valuable nutritional characteristics

Contract: PON Horizon2020
Project cost: €2.336.625,00
Contribution to spending: €812.156,25
Concessionary Financing: €467.325,00
Date: June 2021

Corporate training

Support for the organization and delivery of the training program aimed at strengthening the capacity building of local public administrations in the field of Public Private Partnership (PPP)

Sector: Public Participate - capacity building of local authorities
Date: 2021

Pisa Sporting Club

Iniziativa acted as financial advisor in structuring the financing transaction for the construction of the Pisa Training Centre.

Sector: Sports Facilities
Deal: €3.000.000,00
Date: 2026

TILES

The first platform for shared entertainment

Program: Horizon - SME Instrument
Project cost: €1.651.720,00
Contribution: €1.156.204,00
Date: October 2015

Model 231 from 2001

Support for the preparation of the company's Organization, Management and Control Model, drawn up pursuant to Legislative Decree 231 of 2001.

Sector: Wholesale trade of street sweeping machines
Turnover: €27.197.845
Date: 2023

CASTLE

CAbin Systems design Toward passenger well-being

Program: HORIZON - Clean Sky2
Project cost: €11.695.656,00
Contribution: €9.533.525,00
Date: July 2016

Technical assistance

Technical support activities to the CPT Regional Unit of Bolzano for the analysis of economic-financial and equity data and processing of economic, financial, management and ESG performance indicators of the complex of Local Public Enterprises (around 115 entities) with a focus on investee companies with direct participation from the Province (22 entities)

Sector: Investee Companies - performance analysis
Date: 2023
Value of turnover of the companies analyzed: From €3 million to €169 million

H3PS

High Power High Scalability Aircraft Hybrid Powertrain

Program: Horizon
Project cost: €4.000.000,00
Contribution: €4.000.000,00
Date: March 2018

ESG strategy

Support in the preparation and definition of the ESG strategy and monitoring indicators of sustainable variables

Sector: Energy and Gas Retailer
Date: 2023

Technical assistance

Technical assistance for programs and interventions co-financed with the ERDF ESF+ 2021-2027 Regional Program, with resources from the Development and Cohesion Fund (FSC 2021-2027).

Sector: Technical Assistance
Date: 2025

Sustainability reports

Support in the preparation of the corporate sustainability report and definition of the ESG strategy and indicators for monitoring sustainable variables

Sector: Polydiagnostic Center
Date: 2024

Sustainability reports

Support in the preparation of the corporate sustainability report and definition of the ESG strategy and indicators for monitoring sustainable variables

Sector: Production of Plastic Materials
Date: 2023

Tecno

Iniziativa Assisted Tecno in the M&A transaction for the acquisition of a 65% stake in Energika Srl; the transaction aims to consolidate the SustainTech practice.

Sector: Energy Services
Deal: Undisclosed
Date: 2024

Model 231 from 2001

Update of the company's Organization, Management and Control Model, drawn up pursuant to Legislative Decree 231 of 2001

Sector: Company subject to the management and coordination of Invitalia National Agency for Attracting Investments and Business Development SpA
Turnover: €11.444.972,00
Date: 2020

Metropolitan City of Rome Capital

Support in the development of school sports facilities through PPP projects. Key activities include drafting regulations, creating internal guidelines to manage the incoming initiatives, and providing technical and financial assistance in their evaluation, as well as training staff on PPP regulations.

Date: 2024-2025/XNUMX/XNUMX

€1.9 billion Production investments supported | €435 billion Investments in Research & Innovation subsidized | 200 active customers with hundreds of completed transactions | 100 Project Financing/PPP Operations Supported | €1.9 billion Production investments supported | €435 billion Investments in Research & Innovation subsidized | 200 active customers with hundreds of completed transactions | 100 Project Financing/PPP Operations Supported |